![]() ![]() ![]() Of these, 16 patients ceased treatment early because of local skin irritation and hence were regarded as treatment failures. There was no response in 66 patients (44%). No control group using placebo was studied because of the private-practice setting.ĭuration of symptoms varied from 1 to 30 years, the mean being 4.7 years. ![]() Questionnaires were evaluated before and 3 months after commencement of treatment. There were 7 patients with grade 1 dyspareunia (intercourse always painful but only occasionally preventing penetration), 83 patients with grade 2 (intercourse always painful preventing penetration on most occasions), and 60 patients with grade 3 (apareunic). Most patients (102) had purely provoked vestibulodynia, whereas 48 had both provoked and unprovoked pain. Provoked vestibulodynia was diagnosed by the presence of pinpoint tenderness confined to the vulvar vestibule. This study aimed to evaluate the effectiveness of topical amitriptyline 2% in sorbolene (cetomacrogol aqueous) cream in the management of patients with entry dyspareunia caused by provoked vestibulodynia.Ī prospective study of 150 patients presenting with entry dyspareunia to a private gynecologist (R.P.) was undertaken during a 12-month period.
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